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More →OpenAI Buys Orchestra Bio to Put AI Agents in Charge of Drug Development Grunt Work
OpenAI has bought Orchestra Bio, a San Francisco startup whose AI agents help drug companies keep sprawling development programs on schedule, the ChatGPT maker <a href="https://openai.com/index/openai-to-acquire-orchestra-bio/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>announced Tuesday</a>. “Our goal is to help scientists make discoveries and manage the work needed to turn them into treatments that reach patients sooner,” OpenAI said in the announcement. Orchestra’s team and platform will be folded into <a href="https://openai.com/rosalind/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>Rosalind</a>, OpenAI’s family of AI models and tools for biologists and chemists. The financial terms were not disclosed. Getting a new medicine from first idea to U.S. approval takes time—up to 15 years according to OpenAI. Every month shaved off that timeline is a month earlier that a new treatment can reach the people waiting for it, and a month earlier that the company can generate cash. The process is also absurdly expensive: bringing one approved drug to market can cost more than <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12668846/" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>$2.6 billion</a>, and <a href="https://arxiv.org/pdf/2106.05386" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">fewer than 10%</a> of candidates that enter human testing ever make it to pharmacy shelves. Beyond the science itself, OpenAI says drug teams have to coordinate work across internal departments and outside partners, often relying on systems that don’t talk to each other. Those partners usually include contract research organizations, the outside labs hired to run studies, and contract manufacturers that produce the experimental drug. Orchestra’s AI agents—software that can watch over tasks and flag problems on its own—work out which activities and deadlines take the hit, gather the relevant information and compare ways to respond, while scientists and program leaders make the final call. Founded in the fall of 2022, Orchestra raised its <a href="https://jobs.8vc.com/companies/orchestra/jobs/28818089-senior-software-engineer" target="_blank" rel="nofollow external noopener" class="sc-adb616fe-0 dJryYS">>seed round</a> from Andreessen Horowitz, Definition Capital, Insight Partners, and 8VC, and about $20 million in total, according to <a href="https://www.caplight.com/company/orchestra-bio" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">Caplight data</a>. The company should not be confused with Orchestra BioMed, an unrelated Nasdaq-listed medical device maker that trades under the ticker OBIO. In April, OpenAI launched <a href="https://decrypt.co/364783/openai-gpt-rosalind-drug-discovery-life-sciences-model" target="_blank" class="sc-adb616fe-0 dJryYS" rel="nofollow">GPT-Rosalind</a>, a model built specifically for biology and dru
Crypto Long & Short: Why real-world assets need fixed-rate loans onchain
You're reading <a href="/newsletters/crypto-long-short/" rel="nofollow" target="_blank">Crypto Long & Short</a>, our weekly newsletter featuring insights, news and analysis for the professional investor. <a href="/newsletters/crypto-long-short/" rel="nofollow" target="_blank">Sign up here</a> to get it in your inbox every Wednesday. This is your institutional newsletter, Crypto Long & Short. This week: <em>…and if you’re looking for more institutional insights: ETF Central’s <a href="https://www.etfcentral.com/global-etf-survey/2026" target="_blank" rel="noopener noreferrer">>Trackinsight Global ETF Survey 2026</a>, produced with Calamos Investments and S&P Dow Jones Indices, finds nearly 7 in 10 professional investors are reassessing their ETF holdings.</em> <em>Plus, CoinDesk’s latest <a href="/research/digital-assets-quarterly-review-and-outlook-q3" rel="nofollow" target="_blank">Digital Assets Quarterly Report</a> is out now.</em> <a href="https://www.linkedin.com/in/kim-klemballa-80101812/" target="_blank" rel="noopener noreferrer">>- Kim Klemballa</a> <em>by <a href="/author/peter-gaffney" rel="nofollow" target="_blank">Peter Gaffney, co-founder, O2O Capital Partners</a></em> Fixed-rate lending is the clearest growth lever for real-world assets (RWAs) in decentralized finance (DeFi). It unlocks a strategy that credit desks have run for decades but DeFi has never meaningfully implemented: buy a quality income asset, borrow against it at a locked rate below the asset’s yield and buy more of the asset. Stablecoins are steadily sitting around $300 billion in <a href="https://app.rwa.xyz/stablecoins" target="_blank" rel="noopener noreferrer">>supply</a> and aggregate <a href="https://o2ocapital.com/research/rwa-vaults-institutional-track-record" target="_blank" rel="noopener noreferrer">>vault assets</a> are nearing the $20 billion milestone. Morpho alone carries more than <a href="https://data.morpho.org/" target="_blank" rel="noopener noreferrer">>$16 billion</a> in deposits, most of it in variable-rate markets priced on pool utilization, which serve crypto-native traders who manage liquid positions in real time but leave longer-dated borrowers with uncertainty. Fixed-rate, fixed-term lending closes that gap by matching the term of the loan to the duration of the collateral, especially for RWAs whose redemptions can settle anywhere from T+7 to T+90. With the borrow cost and maturity known at entry, institutional counterparties can underwrite an RWA looping vault the same way they approve conventional term financing. This is the same bedrock foundation that formed and grew traditional credit markets to $51 trillion in US <a href="https://www.sifma.org/research/statistics/research-quarterly-fixed-income-outstanding" target="_blank" rel="noopener noreferrer">>fixed income</a> versus $1.6 trillion in <a href="https://www.lsta.org/content/morningstar-lsta-leveraged-loan-index-analysis-december-2025/" target="_blank" rel="noopener noreferrer">
A Malaysian court retained 322 bitcoins and returned only 176 to the victims.
CoinWorld news: A Malaysian court has ruled to retain the 322 bitcoins, worth approximately $27 million, seized in the 2015-16 Bitkingdom fraud case, and to return only 176 bitcoins to nine victims.
Jiangbolong: High-end products have achieved substantive commercial breakthroughs, and HLC technology has completed joint tuning with Qualcomm and others.
According to CoinWorld news, Longsys stated on its interactive platform that the company is pursuing a development strategy of fully embracing edge AI. High-end products such as UFS4.1, MSSD, and EPOP5X have achieved substantive commercial breakthroughs. HLC technology has completed joint tuning with major chip manufacturers such as AMD, Qualcomm, and UNISOC. HLC technology offers advantages in cost optimization and local deployment of AI large models.
The Trump administration cracks down on crypto fraud, focusing on Telegram markets and USDT wallets.
CoinWorld news: The Trump administration held a meeting at the White House on October 21, 2026, to showcase its crackdown on international cryptocurrency fraud networks. According to FBI data, Americans reported $11.37 billion in crypto-related losses in 2025, accounting for more than half of all cybercrime losses. The Department of Justice said it has frozen approximately $938 million in digital assets tied to fraudulent activities. The meeting is expected to be attended by officials including the Secretary of Homeland Security, the FBI Director, the Secretary of Defense, and the Attorney General. Executive Order 14390, signed by Trump in March, requires prosecutors to prioritize scam center cases and allows the State Department to impose sanctions on countries that tolerate such activities. The Department of Justice's Scam Center Strike Force, established in November 2025, has taken multiple actions, including freezing $52.8 million across 52 wallets.
Jiangsu Xinde Semiconductor Technology Co., Ltd. has passed the listing hearing of the Hong Kong Stock Exchange.
Jiangsu Xinde Semiconductor Technology Co., Ltd. has passed the Hong Kong Stock Exchange listing hearing. According to Cailianshe on October 21, Livermore Securities shows that Jiangsu Xinde Semiconductor Technology Co., Ltd. has updated its post-hearing information pack, meaning the company has passed the hearing for its Hong Kong IPO.
ETH breaks through the $2,500 mark.
CoinWorld data: ETH/USD is currently at $2,500.70, up 0.74% in 5 minutes. Please be aware of market volatility.
Staked Ethereum reaches a record high of 36.4% of total supply.
According to data from Bijie.com, the proportion of staked ETH in the total supply has reached a record high of 36.4%. Since the beginning of 2026, this proportion has risen by 6.55 percentage points from 29.8%.
France made its position clear from the very beginning.
According to CoinWorld news, French President Macron: France made its position clear from the very beginning—the war in Iran is not France's war, and France supports peace.
According to the Ukrainian RBC news agency, citing Ukrainian negotiators, Ukraine has discussed the situation in the Oleshky area occupied by Russian forces with the US side.
According to a report by Ukraine's RBC news agency citing Ukrainian negotiators, Ukraine has discussed with the US side the situation in the Oleshky area occupied by Russian forces.